APA
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Contreras–Briceño, F., Vega, J., Mandiola, J. R., Ocaranza, M., Herrera, S., Salinas, M., … Gabrielli, L. (2021). Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. Journal of Cardiovascular Development and Disease.
Chicago/Turabian
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Contreras–Briceño, Felipe, J. Vega, Jorge R. Mandiola, M. Ocaranza, Sebastián Herrera, M. Salinas, R. Fernández, et al. “Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners.” Journal of Cardiovascular Development and Disease (2021).
MLA
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Contreras–Briceño, Felipe, et al. “Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners.” Journal of Cardiovascular Development and Disease, 2021.
BibTeX Click to copy
@article{felipe2021a,
title = {Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners},
year = {2021},
journal = {Journal of Cardiovascular Development and Disease},
author = {Contreras–Briceño, Felipe and Vega, J. and Mandiola, Jorge R. and Ocaranza, M. and Herrera, Sebastián and Salinas, M. and Fernández, R. and Jalil, J. and Lavandero, S. and Chiong, M. and Godoy, Paz and Castro, P. and Sitges, M. and Gabrielli, L.}
}
This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDRs) during the training period before a marathon race. Thirty-six healthy male LDRs (37.0 ± 5.3 years; 174.0 ± 7.0 height; BMI: 23.8 ± 2.8; V˙ O2-peak: 56.5 ± 7.3 mL·kg−1·min−1) were separated into two groups according to previous training level: high-training (HT, n = 16) ≥ 100 km·week−1 and low-training (LT, n = 20) ≥ 70 and < 100 km·week−1. Also, twenty-one healthy nonactive subjects were included as a control group (CTR). A transthoracic echocardiography was performed and ROCK activity levels in circulating leukocytes were measured at rest (48 h without exercising) the week before the race. The HT group showed a higher left ventricular mass index (LVMi) and left atrial volume index (LAVi) than other groups (p < 0.05, for both); also, higher levels of ROCK activity were found in LDRs (HT = 6.17 ± 1.41 vs. CTR = 1.64 ± 0.66 (p < 0.01); vs. LT = 2.74 ± 0.84; (p < 0.05)). In LDRs a direct correlation between ROCK activity levels and LVMi (r = 0.83; p < 0.001), and LAVi (r = 0.70; p < 0.001) were found. In conclusion, in male competitive long-distance runners, the load of exercise implicated in marathon training is associated with ROCK activity levels and the left cardiac remodelling process assessed by echocardiography.